Berberine, a yellow-colored, bitter-tasting natural plant extract, is showing great promise in helping to protect blood vessels from plaque buildup and atherosclerosis. Atherosclerosis is a serious disease where arteries become thick and stiff due to fatty plaque buildup, which can lead to heart attacks or strokes. This new research, published in 2021, explains how berberine could slow or even stop the progression of this disease.
What is Atherosclerosis?
Atherosclerosis happens when blood vessels, called arteries, become damaged. The walls of arteries become inflamed, and fatty substances collect there. Over time, buildup stiffens and becomes plaque that blocks blood flow.Â
Factors like unhealthy cholesterol levels, inflammation, and damaged blood vessel cells can worsen the problem. And if left untreated, it can cause major health problems like heart disease or stroke.
How Does Berberine Help?
Berberine is a natural compound found in Chinese herbs. For hundreds of years, it has been used to treat infections and stomach issues as traditional medicine.
Now, scientists are studying how effective it can be in treating heart diseases and related conditions.Â
Recent research shows berberine can help in many ways:
- Protecting Blood Vessel Cells: Berberine helps stop damage to the cells lining blood vessels. This reduced inflammation means smooth walls of arteries and minimum plaque buildup.
- Stopping Muscle Cell Growth: Inside blood vessels, smooth muscle cells can grow too much and cause the walls to thicken. Berberine also slows this process.
- Lowering Cholesterol: High cholesterol is a major cause of plaque buildup. Studies show besides reducing blood vessel inflammation and stopping muscle cell growth, berberine also reduces “bad cholesterol” (LDL)Â and triglycerides. Thus, it boosts the body’s ability to remove cholesterol.
- Reducing Inflammation: Berberine also fights overall chronic inflammation, which plays a big role in the progression of atherosclerosis.
What do the Studies Show?
These animal studies have shown amazing results of berberine use. Mice and rats treated with berberine had lower cholesterol, reduced inflammation, and better blood flow.Â
Even, in some cases, berberine lowered harmful triglycerides by over 50%. When combined with statins, a common cholesterol-lowering drug, the results were even better.
Human studies have also been encouraging. In one clinical trial, people with high cholesterol took berberine for three months. Their total cholesterol dropped by 29%, and triglycerides fell by 35%.Â
Another study with overweight people showed similar results, with weight loss as an added benefit.
Berberine has also been tested in people with obesity, diabetes, high blood pressure and cancer. It has effectively reduced blood sugar and blood pressure, and improved heart health. These positive effects of berberine make it a potential all-in-one treatment for several conditions that lead to heart disease.
Effectiveness of these Findings
Atherosclerosis and heart disease are leading causes of death worldwide. Many treatments exist, but they are not always effective for everyone.Â
Statins, for example, can lower cholesterol but may cause side effects for some people. In comparison to already adopted treatment options, Berberine offers a natural alternative that can work alongside other treatments.
Berberine for Heart Health: The Road Ahead
Indeed, the results of these studies on berberine are promising. However, more work is needed to fully adopt berberine as a mainstream treatment option against plaque buildup in arteries. Scientists are still studying how berberine works in the body and the best dose for humans.Â
Some clinical trials are still ongoing.
Berberine could soon become a valuable tool in the fight against atherosclerosis and heart disease. Its natural origins and multiple benefits make it a unique option. As research continues, it may offer new hope to millions worldwide.
For now, the evidence is clear: berberine has the potential to protect blood vessels, reduce cholesterol, and improve heart health.